Research Literature Regarding HBOT Treatment

General Efficacy, Mechanisms and Outcomes

Stephen R. Thom, Veena M. Bhopale, Omaida C. Velazquez, Lee J. Goldstein, Lynne H. Thom and Donald G. Buerk. 2006. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology. Volume 290 Issue 4 April 2006: Pages H1378-H1386.

Goldman RJ. Hyperbaric oxygen therapy for wound healing and limb salvage: a systematic review. PM & R The Journal of Injury, Function and Rehabilitation. 2009 May. 1(5):471-89.

Audiology

Bayoumy, A.B. & de Ru, J.A. The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review. European Archives of Otorhinolaryngology (2019) 276: 1859.

Wang Y, Gao Y, Wang B, Chen L and Zhang X. Efficacy and Prognostic Factors of Combined Hyperbaric Oxygen Therapy in Patients With Idiopathic Sudden Sensorineural Hearing Loss. American Journal of Audiology. 2019 Mar 15; 28(1):95-100.

Holy R, Prazenica P, Stolarikova E, Dosel P, Fundova P, Kovar D and Astl J. Hyperbaric oxygen therapy in tinnitus with normal hearing in association with combined treatment. Journal of the Undersea & Hyperbaric Medical Society. 2016 May-Jun; 43(3):201-5.

İsa Kaya, Baha Sezgin, Sevinç Eraslan, Kerem Öztürk, Sercan Göde, Cem Bilgen, and Tayfun Kirazlı. Malignant Otitis Externa: A Retrospective Analysis and Treatment Outcomes. Turkish Archives of Otorhinolaryngology. 2018 Jun; 56(2): 106–110.

Jefferson C. Davis, MD; George A. Gates, MD; Charles Lerner, MD; Merrit G. Davis Jr, DO; Jon T. Mader, MD and Alan Dinesman, MD. Adjuvant Hyperbaric Oxygen in Malignant External Otitis. JAMA Otolarynology Head & Neck Surgery. 1992;118(1):89-93.

Fattori B1, Nacci A, Casani A, Donati C and De Iaco G. Oxygen therapy in the long term treatment of Meniere’s disease. Acta Otorhinolaryngol Italica. 2001 Feb;21(1):1-9.Bayoumy, A.B. & de Ru, J.A. The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review. European Archives of Otorhinolaryngology (2019) 276: 1859.

Wang Y, Gao Y, Wang B, Chen L and Zhang X. Efficacy and Prognostic Factors of Combined Hyperbaric Oxygen Therapy in Patients With Idiopathic Sudden Sensorineural Hearing Loss. American Journal of Audiology. 2019 Mar 15; 28(1):95-100.

Holy R, Prazenica P, Stolarikova E, Dosel P, Fundova P, Kovar D and Astl J. Hyperbaric oxygen therapy in tinnitus with normal hearing in association with combined treatment. Journal of the Undersea & Hyperbaric Medical Society. 2016 May-Jun; 43(3):201-5.

İsa Kaya, Baha Sezgin, Sevinç Eraslan, Kerem Öztürk, Sercan Göde, Cem Bilgen, and Tayfun Kirazlı. Malignant Otitis Externa: A Retrospective Analysis and Treatment Outcomes. Turkish Archives of Otorhinolaryngology. 2018 Jun; 56(2): 106–110.

Jefferson C. Davis, MD; George A. Gates, MD; Charles Lerner, MD; Merrit G. Davis Jr, DO; Jon T. Mader, MD and Alan Dinesman, MD. Adjuvant Hyperbaric Oxygen in Malignant External Otitis. JAMA Otolarynology Head & Neck Surgery. 1992;118(1):89-93.

Fattori B1, Nacci A, Casani A, Donati C and De Iaco G. Oxygen therapy in the long term treatment of Meniere’s disease. Acta Otorhinolaryngol Italica. 2001 Feb;21(1):1-9.

Fattori B1, De Iaco G, Nacci A, Casani A and Ursino F. Alternobaric oxygen therapy in long-term treatment of Ménière’s disease. Journal of the Undersea & Hyperbaric Medicine Society. 2002 Winter; 29(4):260-70.

Infectious Disease

Sison-Martinez J, Cooper JS. Hyperbaric Treatment Of Clostridial Myositis And Myonecrosis. [Updated 2019 Jun 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan.

Hanley ME, Cooper JS. Chronic Refractory Osteomyelitis. [Updated 2019 May 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan.

Allison GM, Berenson M, McCabe S, Dileo F, Poole M, Fares M, Watson K, Shernoff C, Turkette M, Serrano A and Iafrati M. Chronic Refractory Osteomyelitis Treated with Hyperbaric Oxygen Therapy. Annals of Orthopaedics, Trauma and Rehabilitation. 2018; 1(3):125.

Wilkinson D, Doolette D. Hyperbaric Oxygen Treatment and Survival From Necrotizing Soft Tissue Infection. Arch Surg. 2004;139(12):1339–1345. DOI: 10.1001/archsurg.139.12.1339.

Goerger E, Honnorat E, Savini H, et al. Anti-infective therapy without antimicrobials: Apparent successful treatment of multidrug resistant osteomyelitis with hyperbaric oxygen therapy. IDCases. 2016;6:60–64. Published 2016 Sep 28. DOI:10.1016/j.idcr.2016.09.008.

Nephrology

Shilo Y, Efrati S, Simon Z, Sella A, Gez E, Fenig E, Wygoda M, Lindner A, Fishlev G, Stav K, Zisman A, Siegel YI, Leibovici D. Hyperbaric oxygen therapy for hemorrhagic radiation cystitis. Isr Med Assoc J. 2013 Feb;15(2):75-8.

Degener, S., Pohle, A., Strelow, H. et al. Long-term experience of hyperbaric oxygen therapy for refractory radio- or chemotherapy-induced hemorrhagic cystitis. BMC Urol 15, 38 (2015) doi:10.1186/s12894-015-0035-4.

Cooper JS, Hanley ME. Hyperbaric Treatment Of Radiation Proctitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan.

An J, Devaney B, Ooi KY, Ford S, Frawley G, Menahem S. Hyperbaric oxygen in the treatment of calciphylaxis: A case series and literature review. Nephrology (Carlton). 2015 Jul;20(7):444-50. doi: 10.1111/nep.12433.

Neurology

Vincenzo Spina, Francesco Tomaiuolo, Lorenzo Celli, Luca Bonfiglio, Luca Cecchetti, and Maria Chiara Carboncini. A Case of Carbon Monoxide-Induced Delayed Neurological Sequelae Successfully Treated with Hyperbaric Oxygen Therapy, N-Acetylcysteine, and Glucocorticoids: Clinical and Neuroimaging Follow-Up. Case Reports in Neurological Medicine, vol. 2019, Article ID 9360542, 7 pages, 2019. https://doi.org/10.1155/2019/9360542.

Paul Harch, Edward Fogarty. Subacute normobaric oxygen and hyperbaric oxygen therapy in drowning, reversal of brain volume loss: a case report. Medical Gas Research, 2017; 7 (2): 144 DOI: 10.4103/2045-9912.208521.

Peterson K, Bourne D, Anderson J, et al. Evidence Brief: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury and/or Post-traumatic Stress Disorder. 2018 Feb. In: VA Evidence Synthesis Program Evidence Briefs [Internet]. Washington (DC): Department of Veterans Affairs (US); 2011.

Oncology

Stępien K, Ostrowski RP, Matyja E. Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours. Med Oncol. 2016;33(9):101. doi:10.1007/s12032-016-0814-0.

Moen I, Stuhr LE. Hyperbaric oxygen therapy and cancer–a review. Target Oncol. 2012;7(4):233–242. doi:10.1007/s11523-012-0233-x.

Chen, Yen-Chen, Shao-yuan Chen, Pey-Shen Ho, Chia-huei Lin, Ya-Yuan Cheng, Jehng-Kang Wang and Huey-Kang Sytwu. Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK. Leukemia research 31 6 (2007): 805-15.

Qi Y, Ruan J, Wang M, et al.Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901. Biomed Rep. 2017;6(4):475–479. doi:10.3892/br.2017.869.

Pande S, Sengupta A, Srivastava A, Gude RP, Ingle A. Re-Evaluate the Effect of Hyperbaric Oxygen Therapy in Cancer – A Preclinical Therapeutic Small Animal Model Study. Nov 2012 PLoS ONE 7(11): e48432. doi:10.1371/journal.pone.0048432.

Huang L, Boling W, Zhang JH. Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiforme. Med Gas Res. 2018;8(1):24–28. Published 2018 Apr 18. doi:10.4103/2045-9912.229600.

Oral & Maxillofacial/ Dental

Re K, Patel S, Gandhi J, Suh Y, Reid I, Joshi G, Smith NL, Khan SA. Clinical utility of hyperbaric oxygen therapy in dental and oral medicine. Med Gas Res. 2019;9(3):138. doi:10.4103/2045-9912.267001.

Devaraj D, Srisakthi D. Hyperbaric oxygen therapy – can it be the new era in dentistry? J Clin Diagn Res. 2014;8(2):263–265. doi:10.7860/JCDR/2014/7262.4077

Orthopedics

Huang KC, Hsu WH, Peng KT, Huang TJ, Hsu RW. Hyperbaric oxygen therapy in orthopedic conditions: an evaluation of safety. J Trauma. 2006 Oct; 61(4):913-7.

Barilaro G, Francesco Masala I, Parracchini R, Iesu C, Caddia G, Sarzi-Puttini P, Atzeni F. The Role of Hyperbaric Oxygen Therapy in Orthopedics and Rheumatological Diseases. Isr Med Assoc J. 2017 Jul; 19(7):429-434.

Kyeong-Mee Park, Changdae Kim, Wonse Park, Young-Bum Park, Moon-Kyu Chung, and Sungtae Kim. Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats. BioMed Research International, vol. 2019, Article ID 9051713, 9 pages, 2019. doi:10.1155/2019/9051713.

Jure Aljinović, Dinko Pivalica, Ivanka Marinović, Ana Poljičanin, Tonko Vlak, Hrvoje Stipančević, Dušanka Martinović-Kaliterna and Davor Čarić. Hyperbaric Oxygen Therapy as a Therapy Option in the Early Phase of Avascular Necrosis of the Femoral Head. International Journal of Physiatry. Case Report, Vol 2 Issue 2, DOI: 10.23937/2572-4215.1510010.

Sammarco MC, Simkin J, Cammack AJ, et al. Hyperbaric Oxygen Promotes Proximal Bone Regeneration and Organized Collagen Composition during Digit Regeneration. PLoS One. 2015;10(10):e0140156. Published 2015 Oct 9. doi:10.1371/journal.pone.0140156.

Plastic & Reconstructive Surgery

Sourabh Bhutani and Guruswamy Vishwanath. Hyperbaric oxygen and wound healing. Indian Journal of Plastic Surgery. 2012 May-Aug; 45(2): 316–324.

Stong BC, Jacono AA. Effect of Perioperative Hyperbaric Oxygen on Bruising in Face-lifts. Arch Facial Plast Surg. 2010;12(5):356–358. doi: 10.1001/archfacial.2010.66

Fife, Caroline E. MD; Eckert, Kristen A. MPhil; Carter, Marissa J. PhD, MA. An Update on the Appropriate Role for Hyperbaric Oxygen: Indications and Evidence. Plastic and Reconstructive Surgery: September 2016 – Volume 138 – Issue 3S – p 107S-116S. doi:10.1097/PRS.0000000000002714

Kindwall EP, Gottlieb LJ, Larson DL. Hyperbaric oxygen therapy in plastic surgery: a review article. Plast Reconstr Surg. 1991 Nov;88(5):898-908. DOI: 10.1097/00006534-199111000-00029

Podiatry

David Swain, DPM, CWSP. HBOT: What The Studies Show. Podiatry Today. Vol 28, Issue 8, August 2015; 48-54.

Kazu Suzuki, DPM, CWS. A Closer Look At HBOT For Foot And Ankle Indications. Podiatry Today, Vol 28, Issue 1, January 2015; 32-33.

Health Quality Ontario. Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: A Health Technology Assessment. Ont Health Technol Assess Ser. 2017;17(5):1–142. Published 2017 May 12.

Additional Research

Some examples of the promising research being conducted into additional uses for hyperbaric oxygen.

Atzeni F, Casale R, Alciati A, Masala IF, Batticciotto A, Talotta R, Gerardi MC, Salaffi F, Sarzi-Puttini P. Hyperbaric oxygen treatment of fibromyalgia: a prospective observational clinical study. Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):63-69. Epub 2019 Feb6.

Efrati S, Golan H, Bechor Y, Faran Y, Daphna-Tekoah S, Sekler G, Fishlev G, Ablin JN, Bergan J, Volkov O, Friedman M, Ben-Jacob E, Buskila D. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial. PLoS One. 2015 May 26;10(5):e0127012. doi: 10.1371/journal.pone.0127012. eCollection 2015.

Michelle R.Reillo, Raymond, J.Altieri. HIV antiviral effects of hyperbaric oxygen therapy. Journal of the Association of Nurses in AIDS Care. Vol 7 Issue 1, January–February 1996; 43-45.

Corklin R. Steinhart, Ivan Montoya, Donna A. Jacobsen, Pippa S. Steinhart, Mary Stein-Ferrer, and Marc R. Kaiser. The Effect of Hyperbaric Oxygenation (HBO) on HIV-Associated Chronic Fatigue and Peripheral Neuropathy. Alternative and Complementary Therapies. Jul 1996. Vol 2 Issue 4: Feb 3, 2009. doi:10.1089/act.1996.2.236

Reillo MR. Hyperbaric oxygen therapy for the treatment of debilitating fatigue associated with HIV/AIDS. Journal of the Association of Nurses in AIDS Care. 1993 Jul-Sep;4(3):33-8.

Clayton, E. O., Njoku-Austin, C., Scott, D., Cain, J. D., & Hogan, M. V. (2023). Racial and ethnic disparities in the management of diabetic feet. Current Reviews in Musculoskeletal Medicine, 16(11), 550–556.

Diabetes and your feet. (2023, April 11). Centers for Disease Control and Prevention.

Diabetes Disparities in Medicare Fee-For-Service Beneficiaries. (2021, November). cms.gov.

National Diabetes Statistics Report. (2023, November). www.cdc.gov. 

Parker, E. D., Lin, J. D., Mahoney, T. J., Ume, N., Yang, G., Gabbay, R. A., ElSayed, N. A., & Bannuru, R. R. (2023). Economic costs of diabetes in the U.S. in 2022. Diabetes Care. 

Spampinato, S. F., Caruso, G. I., De Pasquale, R., Sortino, M. A., & Merlo, S. (2020). The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs. Pharmaceuticals, 13(4), 60.

World Health Organization: WHO & World Health Organization: WHO. (2023b, April 5). Diabetes.